IgG 1 antibodies show themselves to be more adhesive, and readily bind to any antigens. This sequence of events is thought to be the most common way individuals develop adverse reactions to foods, which they consume on a regular basis. These complexes can also be deposed in tissue or organs, leading to damage, which can cause uncomfortable and nuisance symptoms to an individual. The inflammatory response to a food is the main cause of symptoms in this type of food reaction resulting from food intolerance. From then, these larger complexes are able to activate the complement cascade, initiating inflammatory responses in the body, and thus are detectable through blood testing. Basically, you are able to learn and understand the food items your body can tolerate, or, no longer tolerate and take steps to make changes with confidence.Īs a result of this, the complexes will get larger. It reduces the incidence of patients removing too many foods and doing so unnecessarily, therefore improving patient compliance and outcome. Therefore testing for IgG4 over IgG1 or total IgG is an advantage, as it leads to a reduced number of false-positives and allows for much more targeted, relevant results. If you’d like to understand the deeper science behind the production of IgG1 and IgG4 antibodies click here. IgG1 antibodies are like ‘first responders’ and are produced in response to new food antigens whereas IgG4 antibodies are produced when the body is continually exposed to an antigen. The main difference between IgG1 and IgG4 is how they respond to food antigens. IgG2 and IgG3 are not generally produced in response to food antigens. Of the four subclasses the most commonly tested are IgG1 and IgG4, as these are produced in response to food antigens and therefore can be used to identify intolerances. There are a range of IgG tests, which are available to health professionals all over the world, some testing all subclasses and others testing one subclass but there are on-going discussions about which is the most effective. Within the IgG class there are four IgG subclasses. In order to test for immune-mediated intolerances specifically, testing for IgG antibodies is required. This is helping spread awareness about potential symptoms and the benefits of testing. Nutrition as a topic and, more specifically allergies, intolerances and sensitivities, are getting more coverage than ever in the media. It is a constant talking point for both health professionals and their patients. Why Do We Test IgG 4 Over Total IgG Or IgG 1?įood allergies, intolerances and sensitivities are becoming more topical in a variety of sectors in the healthcare industry.
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